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Botulinum Toxin - 1 Vial x 150 IU

Botulinum Toxin - 1 Vial x 150 IUPackage: 1 Vial x 150 IU

Usage: Injectable

Botox (Botulinum toxin type A) is used cosmetically to improve facial wrinkles,also to treat strabismus,spasm of the eyelids,blepharospasm,severe underarm sweating,etc.

Produced by: China


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Botulinum Toxin type A 150 IU, Buy Botulinum Toxin type A 150 IU Online


Brand name: Botulinum Toxin 150 IU, BTXA;
Generic name: Botulinum Toxin;
Active ingredient: botulinum toxin type A;
Inactive ingredients: human albumin and sodium chloride;
Manufacturer: China;
BTXA (Botulinum Toxin Type A for Therapy)

DESCRIPTION:
Botulinum Toxin Type A is type-A toxin that encloses 150 IU in one vial and can be indicated into one man. Botulinum Toxin Type A is a type of preparation to correct small folds and shrink the face.
This injection is a hygienic, lyophilized formula of cleaned botulinum toxin type A, created from the crude toxin of the culture of the Hall strain of Clostridium botulinum developed in a medium having trypticase and yeast extract. A sequence of cleansing process were extracted to make a crystal-like complex containing of the active high molecular weight toxin protein also an allied hemagglutinin. Next re-diluted and dialyzed the clear toxin, a correct amount of the germ-free cleaned (0.2 microns) toxin were added to a solution containing gelatin-dextran-sucrose, and then lyophilized. Every vial of BTXA contains 100 or 50 units (U) of C. botulinum toxin type A, 5 mg of gelatin, 25 mg of dextran and 25 mg of sucrose.

INDICATIONS:
This medication is administrated for the treatment of blepharospasm, hemi facial tremor in adults also some sorts of strabismus, mainly for important paralytic strabismus, comitant strabismus, strabismus caused by endocrine myopathy also strabismus which cannot be amended with surgery. Anti-Wrinkle, Thin faces and legs.

USAGE AND DOSING:
1. Location for injection:
- For blepharospasm: the inoculation should be used intramuscularly at some locations of superior and lower tops, i.e., taking 4 to 5 points of injection into orbicularis oculi of medial and lateral or lateral canthus temporal.
- For hemi facial spasm: besides the points mentioned above, three other points on middle, lower face also cheek should be injected intramuscularly. BTXA (Botulinum Toxin Type A for Therapy) may be injected at the locations of two sides of eyebrow, upper lip or the lower jaw agreeing to the illnesses.
- For strabismus: the BTXA is inserted using a coaxial electrode syringe with electromyography control or amplifier under topical anesthesia of 0.5% Decarine. The insertions into additional ocular muscles are selected agreeing to the form and point of strabismus.

2. Dosing:
150 IU have to be diluted into 2.0-2.5ml sterilized water before administrating.
Melt with sterile normal saline agreeing to diverse requirements before administrating. The white loose product turns to be neutral or yellowish translucent solution after the melting.
- For blepharopasm and hemi facial spasm: the insertion can be suggested following above directions. The first dose of each point is 2.5 U/ 0.05ml or 2.5 U / 0.1 ml. If the first handling is considered insufficient 1 week later, a supplementary inoculation can be indicated. Double measure of 5 U / 0.1 ml can be given to recrudescent individuals. But the limitation of total dose of 55 U for one insertion and 200 U for one month must not be exceeded.
- For strabismus: for vertical and horizontal muscle strabismus of less than 20 prism diopters, the first dose into each muscle is 1.25-2.5 U; for horizontal strabismus of 20-40 prism diopters, the initial measure into every muscle is 2.5 U; for horizontal strabismus of 40-50 prism diopters, the initial dose into each muscle is 2.5 U as well can be increase (to 5.0 every) depending on the reaction; for persistent VI cranial nerve paralysis lasted for more than 1 month. The inserting volume into ever muscle has to not exceed 0.1 ml. To people, having insufficient result, extra injection may be given. To recrudescent patients, the measure can be repeated or amplified irregularly. But for every muscle the supreme measure should be less than 5 U / inj.

The Watering of BTXA (Botulinum Toxin Type A for Therapy):
The dissolving of this preparation with sterile normal saline should be done carefully on the basis of real necessities. Following is a reference table of dilution to be suggested. The vial should be shaking mildly once adding sterile normal saline to the complete watering. The reconstituted BTXA should be administrated at once or stored in ice-box at 2 to 8 degrees as well to be used within 4 hours. The container as well as the syringe used with this injection also the lasting BTXA solution should be disposed after purification.

UNUSUAL REACTIONS:
Passing ptosis of the eyelid, drawback of the minor eyelid, reduced blinking, eyelid close partly, dimless of facial muscles, etc. can occur to a few patients who received this injection cure for blepharospasm as well hemi facial tremor. But, all the indications will vanish without any treatment within three to eight weeks. Momentary and dissimilar point of ptosis of the eyelid, vertical deviancy as well rarely mydriasis, which connected to the transmission of the toxin to the muscles adjacent, can appear to some individuals who received this injection therapy for strabismus. The indications will disappear without any treatment within a few weeks.

CONTRAINDICATIONS:
This preparation is not recommended in people with anaphylactic parts as well recognized hypersensitivity to any ingredient.

NOTICES:
The insertion procedure should be suggested later to persons who have infection, serious infectious illness also prudently to the people with heart, liver, lung diseases, active tuberculosis, blood troubles and pregnant women.
Botulinum toxin could be potentiated by aminoglycoside antibiotics (such as gentamicin).This kind of medicines should not be used during the using of BTXA (Botulinum Toxin Type A for Therapy).
BTXA (Botulinum Toxin Type A for Therapy) is in low result or without any effect to the people in the next situations: strabismus above 50 prism diopters, fixed strabismus, strabismus provoked by extremely corrected surgery, chronic paralysis strabismus, also chronic VI or III cranial nerve paralysis, serious muscle fiber contracture.
1:1000 adrenalines have to be set in case of occasional accident.

EXPIRATION:
Three years from the date of lyophilization. The effect is clear and can be last six months.

KEEPING:
Keep at a temperature of -5 to -20 gr C (23 to -4 gr F). Store unused vial at -5 temperatures.

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